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Livres
Articles (249)
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Altered profile of human gut microbiome is associated with cirrhosis and its complications

Bajaj, Jasmohan S., Heuman, Douglas M., Hylemon, Phillip B., Sanyal, Arun J., White, Melanie B., Monteith, Pamela, Noble, Nicole A., Unser, Ariel B., Daita, Kalyani, Fisher, Andmorgan R., Sikaroodi, M

Journal:

Journal of Hepatology

Année:

2014

Langue:

english

Fichier:

PDF, 1.20 MB

english, 2014

Regulation of bile acid synthesis

Z. Reno Vlahcevic, Douglas M. Heuman, Phillip B. Hylemon

Journal:

Hepatology

Année:

1991

Langue:

english

Fichier:

PDF, 1.34 MB

english, 1991

Sulfated oxysterol, 25HC3S, is a potent regulator of lipid metabolism in human hepatocytes

Shunlin Ren, Xiaobo Li, Daniel Rodriguez-Agudo, Gregorio Gil, Phillip Hylemon, William M. Pandak

Journal:

Biochemical and Biophysical Research Communications

Année:

2007

Langue:

english

Fichier:

PDF, 222 KB

english, 2007

Positive and negative regulation of JNK1 by protein kinase C and p42MAP kinase in adult rat hepatocytes

W.David Jarvis, Kelly L Auer, Mark Spector, George Kunos, Steven Grant, Philip Hylemon, Ross Mikkelsen, Paul Dent

Journal:

FEBS Letters

Année:

1997

Langue:

english

Fichier:

PDF, 799 KB

english, 1997

313 25-Hydroxycholesterol-3-Sulfate (25HC3S) Attenuates Hepatocyte Intracellular Lipid Levels and Inflammatory Response via LXR/Srebps and IKB/NF-kB Pathways

Xu, Leyuan, Bai, Qianming, Hylemon, Phillip, Heuman, Douglas M., Pandak, William M., Ren, Shunlin

Journal:

Gastroenterology

Année:

2010

Langue:

english

Fichier:

PDF, 91 KB

english, 2010

Consequences of bile salt biotransformations by intestinal bacteria

Ridlon, Jason M., Harris, Spencer C., Bhowmik, Shiva, Kang, Dae-Joong, Hylemon, Phillip B.

Journal:

Gut Microbes

Année:

2016

Langue:

english

Fichier:

PDF, 1.77 MB

english, 2016

Gut microbiota drive the development of neuro-inflammatory response in cirrhosis

Kang, Dae Joong, Betrapally, Naga S, Ghosh, Siddhartha A, Sartor, R Balfour, Hylemon, Phillip B, Gillevet, Patrick M, Sanyal, Arun J, Heuman, Douglas M, Carl, Daniel, Zhou, Huiping, Liu, Runping, Wang

Journal:

Hepatology

Année:

2016

Langue:

english

Fichier:

PDF, 3.56 MB

english, 2016

Metabolism of hydrogen gases and bile acids in the gut microbiome

Hylemon, Phillip B., Harris, Spencer C., Ridlon, Jason M.

Journal:

FEBS Letters

Année:

2018

Langue:

english

Fichier:

PDF, 618 KB

english, 2018

Endoplasmic Reticulum Stress and Atherosclerosis

Zhou, Huiping, Sun, Lixin, Xiao, Jian, Zhang, Luyong, Li, Xiaokun, Studer, Elaine, Pandak, William, Hylemon, Phillip

Journal:

Current Hypertension Reviews

Année:

2010

Langue:

english

Fichier:

PDF, 281 KB

english, 2010

Regulation of bile acid synthesis. I. Effects of conjugated ursodeoxycholate and cholate on bile acid synthesis in chronic bile fistula rat

Douglas M. Heuman, Carmen R. Hernandez, Philip B. Hylemon, William M. Kubaska, Constance Hartman, Z. Reno Vlahcevic

Journal:

Hepatology

Année:

1988

Langue:

english

Fichier:

PDF, 1007 KB

english, 1988

Regulation of bile acid synthesis. II. Effect of bile acid feeding on enzymes regulating hepatic cholesterol and bile acid synthesis in the rat

Douglas M. Heuman, Z. Reno Vlahcevic, Marsha L. Bailey, Phillip B. Hylemon

Journal:

Hepatology

Année:

1988

Langue:

english

Fichier:

PDF, 761 KB

english, 1988

Cholesterol and bile acid metabolism in cultures of primary rat bile ductular epithelial cells

Dr. Philip B. Hylemon, Patricia M. Bohdan, Alphonse E. Sirica, Douglas M. Heuman, Z. Reno Vlahcevic

Journal:

Hepatology

Année:

1990

Langue:

english

Fichier:

PDF, 827 KB

english, 1990

Conjugates of ursodeoxycholate protect against cytotoxicity of more hydrophobic bile salts: In vitro studies in rat hepatocytes and human erythrocytes

Dr. Douglas M. Heuman, W. Michael Pandak, Philip B. Hylemon, Z. Reno Vlahcevic

Journal:

Hepatology

Année:

1991

Langue:

english

Fichier:

PDF, 701 KB

english, 1991

Role of newly synthesized cholesterol or its metabolites on the regulation of bile acid biosynthesis after short-term biliary diversion in the rat

Z. Reno Vlahcevic, William M. Pandak, Philip B. Hylemon, Douglas M. Heuman

Journal:

Hepatology

Année:

1993

Langue:

english

Fichier:

PDF, 1.04 MB

english, 1993

Effects of different bile salts on steady-state mRNA levels and transcriptional activity of cholesterol 7α-hydroxylase

William M. Pandak, Z. Reno Vlahcevic, Douglas M. Heuman, Kaye S. Redford, John Y. L. Chiang, Philip B. Hylemon

Journal:

Hepatology

Année:

1994

Langue:

english

Fichier:

PDF, 822 KB

english, 1994

Overexpression of cholesterol transporter StAR increases In Vivo rates of bile acid synthesis in the rat and mouse

Shunlin Ren, Phillip B. Hylemon, Dalila Marques, Emily Gurley, Patricia Bodhan, Elizabeth Hall, Kaye Redford, Gregorio Gil, William M. Pandak M.D.

Journal:

Hepatology

Année:

2004

Langue:

english

Fichier:

PDF, 886 KB

english, 2004

Bile acids induce mitochondrial ROS, which promote activation of receptor tyrosine kinases and signaling pathways in rat hepatocytes

Youwen Fang, Song Iy Han, Clint Mitchell, Seema Gupta, Elaine Studer, Steven Grant, Phillip B. Hylemon, Paul Dent

Journal:

Hepatology

Année:

2004

Langue:

english

Fichier:

PDF, 1.32 MB

english, 2004

Bile acids enhance the activity of the insulin receptor and glycogen synthase in primary rodent hepatocytes

Song Iy Han, Elaine Studer, Seema Gupta, Youwen Fang, Liang Qiao, Weiqun Li, Steven Grant, Philip B. Hylemon, Paul Dent

Journal:

Hepatology

Année:

2004

Langue:

english

Fichier:

PDF, 356 KB

english, 2004

Conjugated bile acids promote ERK1/2 and AKT activation via a pertussis toxin–sensitive mechanism in murine and human hepatocytes

Paul Dent, Youwen Fang, Seema Gupta, Elaine Studer, Clint Mitchell, Sarah Spiegel, Philip B. Hylemon

Journal:

Hepatology

Année:

2005

Langue:

english

Fichier:

PDF, 468 KB

english, 2005

Prevention of free fatty acid–induced hepatic lipotoxicity by 18β-glycyrrhetinic acid through lysosomal and mitochondrial pathways

Xudong Wu, Luyong Zhang, Emily Gurley, Elaine Studer, Jing Shang, Tao Wang, Cuifen Wang, Ming Yan, Zhenzhou Jiang, Phillip B. Hylemon, Arun J. Sanyal, William M. Pandak Jr, Huiping Zhou

Journal:

Hepatology

Année:

2008

Langue:

english

Fichier:

PDF, 2.17 MB

english, 2008

Altered levels of phosphoinositide metabolites and activation of guanine-nucleotide dependent phospholipase C in rat hepatic tumors

Narendra D. Lalwani, Philip B. Hylemon, Stephen C. Strom

Journal:

Journal of Cellular Physiology

Année:

1991

Langue:

english

Fichier:

PDF, 1.08 MB

english, 1991

Simultaneous measurement of cholesterol 7α-hydroxylase activity by reverse-phase high-performance liquid chromatography using both endogenous and exogenous [4-14C]cholesterol as substrate

Phillip B. Hylemon, Elaine J. Studer, William M. Pandak, Douglas M. Heuman, Z.Reno Vlahcevic, John Y.L. Chiang

Journal:

Analytical Biochemistry

Année:

1989

Langue:

english

Fichier:

PDF, 455 KB

english, 1989

Synthesis and anti-inflammatory activities of mono-carbonyl analogues of curcumin

Guang Liang, Xiaokun Li, Li Chen, Shulin Yang, Xudong Wu, Elaine Studer, Emily Gurley, Phillip B. Hylemon, Faqing Ye, Yueru Li, Huiping Zhou

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

2008

Langue:

english

Fichier:

PDF, 181 KB

english, 2008

Regulation of p21 and p27 expression by the hepatitis B virus X protein and the alternate initiation site X proteins, AUG2 and AUG3

J KEVIN LEACH, LIANG QIAO, YOUWEN FANG, SONG LY HAN, DONNA GILFOR, PAUL B FISHER, STEVEN GRANT, PHILIP B HYLEMON, DARRELL PETERSON, PAUL DENT

Journal:

Journal of Gastroenterology and Hepatology

Année:

2003

Langue:

english

Fichier:

PDF, 272 KB

english, 2003

Expression inEscherichia coliand characterization of a bile acid-inducible 3α-hydroxysteroid dehydrogenase fromEubacteriumsp. strain VPI 12708

Darrell H. Mallonee, Mark A. Lijewski, Phillip B. Hylemon

Journal:

Current Microbiology

Année:

1995

Langue:

english

Fichier:

PDF, 533 KB

english, 1995

Use of a short A/T-rich cassette for enhanced expression of cloned genes inEscherichia coli

Darrell H. Mallonee, Phillip B. Hylemon

Journal:

Molecular Biotechnology

Année:

1999

Langue:

english

Fichier:

PDF, 1.87 MB

english, 1999

Over-expression of hepatic neutral cytosolic cholesteryl ester hydrolase in mice increases free cholesterol and reduces expression of HMG-CoAR, CYP27, and CYP7A1

Timothy B. Langston, Phillip B. Hylemon, W. M. Grogan

Journal:

Lipids

Année:

2005

Langue:

english

Fichier:

PDF, 570 KB

english, 2005

Mitochondrial cholesterol transport: A possible target in the management of hyperlipidemia

E. A. Hall, S. Ren, P. B. Hylemon, K. Redford, A. del Castillo, G. Gil, W. M. Pandak

Journal:

Lipids

Année:

2005

Langue:

english

Fichier:

PDF, 905 KB

english, 2005

Regulation of Hepatocyte Lipid Metabolism and Inflammatory Response by 25-Hydroxycholesterol and 25-Hydroxycholesterol-3-sulfate

Leyuan Xu, Qianming Bai, Daniel Rodriguez-Agudo, Phillip B. Hylemon, Douglas M. Heuman, William M. Pandak, Shunlin Ren

Journal:

Lipids

Année:

2010

Langue:

english

Fichier:

PDF, 764 KB

english, 2010

High-performance liquid chromatography assay for 3β-hydroxy-Δ5-C27-steroid oxidoreductase activity in rat liver microsomes

Phillip B. Hylemon, Leanne Raynor, Patricia M. Bohdan, Z. Reno Vlahcevic

Journal:

Analytical Biochemistry

Année:

1991

Langue:

english

Fichier:

PDF, 388 KB

english, 1991

Biotransformation of monoterpenes, bile acids, and other isoprenoids in anaerobic ecosystems

P.B. Hylemon, J. Harder

Journal:

FEMS Microbiology Reviews

Année:

1998

Langue:

english

Fichier:

PDF, 377 KB

english, 1998

Hepatitis B virus X protein increases expression of p21Cip-1/WAF1/MDA6 and p27Kip-1 in primary mouse hepatocytes, leading to reduced cell cycle progression

Liang Qiao, Kevin Leach, Robert McKinstry, Donna Gilfor, Adly Yacoub, Jong Sung Park, Steven Grant, Philip B. Hylemon, Paul B. Fisher, Paul Dent

Journal:

Hepatology

Année:

2001

Langue:

english

Fichier:

PDF, 431 KB

english, 2001

Activation of the Raf-1/MEK/ERK cascade by bile acids occurs via the epidermal growth factor receptor in primary rat hepatocytes

Yi-Ping Rao, Elaine J. Studer, R.Todd Stravitz, Seema Gupta, Liang Qiao, Paul Dent, Phillip B. Hylemon

Journal:

Hepatology

Année:

2002

Langue:

english

Fichier:

PDF, 424 KB

english, 2002

Inhibition of the MAPK and PI3K pathways enhances UDCA-induced apoptosis in primary rodent hepatocytes

Liang Qiao, Adly Yacoub, Elaine Studer, Seema Gupta, Xin Yan Pei, Steven Grant, Philip B. Hylemon, Paul Dent

Journal:

Hepatology

Année:

2002

Langue:

english

Fichier:

PDF, 331 KB

english, 2002

Regulation of oxysterol 7α-hydroxylase (CYP7B1) in primary cultures of rat hepatocytes

William M. Pandak, Phillip B. Hylemon, Shunlin Ren, Dalila Marques, Gregorio Gil, Kaye Redford, Darrell Mallonee, Z.Rano Vlahcevic

Journal:

Hepatology

Année:

2002

Langue:

english

Fichier:

PDF, 165 KB

english, 2002

Cyclin kinase inhibitor p21 potentiates bile acid–induced apoptosis in hepatocytes that is dependent on p53

Liang Qiao, Robert McKinstry, Seema Gupta, Donna Gilfor, Jolene J. Windle, Philip B. Hylemon, Steven Grant, Paul B. Fisher, Paul Dent

Journal:

Hepatology

Année:

2002

Langue:

english

Fichier:

PDF, 299 KB

english, 2002

Characterization of a NADH:Flavin oxidoreductase induced by cholic acid in a 7α-dehydroxylating intestinal Eubacterium species

Robert H. Lipsky, Phillip B. Hylemon

Journal:

Biochimica et Biophysica Acta (BBA) - Enzymology

Année:

1980

Langue:

english

Fichier:

PDF, 508 KB

english, 1980

Expression of the bile acid-inducible NADH:flavin oxidoreductase gene of Eubacterium sp. VPI 12708 in Escherichia coli

Stephen F. Baron, Phillip B. Hylemon

Journal:

Biochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology

Année:

1995

Langue:

english

Fichier:

PDF, 1023 KB

english, 1995

Isolation and characterization of a bile acid inducible 7α-dehydroxylating operon in Clostridium hylemonae TN271

Jason M. Ridlon, Dae-Joong Kang, Phillip B. Hylemon

Journal:

Anaerobe

Année:

2010

Langue:

english

Fichier:

PDF, 788 KB

english, 2010

Indinavir alters sterol and fatty acid homeostatic mechanisms in primary rat hepatocytes by increasing levels of activated sterol regulatory element-binding proteins and decreasing cholesterol 7α-hydroxylase mRNA levels

Kris Williams, Yi-Ping Rao, Ramesh Natarajan, W.Michael Pandak, Phillip B. Hylemon

Journal:

Biochemical Pharmacology

Année:

2004

Langue:

english

Fichier:

PDF, 679 KB

english, 2004

Inhibition of insulin/IGF-1 receptor signaling enhances bile acid toxicity in primary hepatocytes

Paul Dent, Song Iy Han, Clint Mitchell, Elaine Studer, Adly Yacoub, Jennifer Grandis, Steven Grant, Geoffrey W. Krystal, Philip B. Hylemon

Journal:

Biochemical Pharmacology

Année:

2005

Langue:

english

Fichier:

PDF, 465 KB

english, 2005

HIV protease inhibitor lopinavir-induced TNF-α and IL-6 expression is coupled to the unfolded protein response and ERK signaling pathways in macrophages

Li Chen, Sirikalaya Jarujaron, Xudong Wu, Lixin Sun, Weibin Zha, Guang Liang, Xuan Wang, Emily C. Gurley, Elaine J. Studer, Phillip B. Hylemon, William M. Pandak Jr., Luyong Zhang, Guangji Wang, Xiaok

Journal:

Biochemical Pharmacology

Année:

2009

Langue:

english

Fichier:

PDF, 525 KB

english, 2009

Biotransformation of monoterpenes, bile acids, and other isoprenoids in anaerobic ecosystems

P.B. Hylemon, J. Harder

Journal:

FEMS Microbiology Reviews

Année:

1998

Langue:

english

Fichier:

PDF, 382 KB

english, 1998

Bile acids as regulatory molecules

Hylemon, P. B., Zhou, H., Pandak, W. M., Ren, S., Gil, G., Dent, P.

Journal:

The Journal of Lipid Research

Année:

2009

Langue:

english

Fichier:

PDF, 1.07 MB

english, 2009

Characterization of active and inactive forms of rat hepatic 3-hydroxy-3-methylglutaryl coenzyme A reductase

Terence R. Whitehead, Z.Reno Vlahcevic, Zafarul H. Beg, Phillip B. Hylemon

Journal:

Archives of Biochemistry and Biophysics

Année:

1984

Langue:

english

Fichier:

PDF, 3.71 MB

english, 1984

Purification and characterization of bile salt hydrolase from Bacteroides fragilis subsp. fragilis

E.J. Stellwag, P.B. Hylemon

Journal:

Biochimica et Biophysica Acta (BBA) - Enzymology

Année:

1976

Langue:

english

Fichier:

PDF, 658 KB

english, 1976

Partial purification and characterization of NAD-dependent 7α-hydroxysteroid dehydrogenase from Bacteroides thetaiotaomicron

J.A. Sherrod, P.B. Hylemon

Journal:

Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism

Année:

1977

Langue:

english

Fichier:

PDF, 684 KB

english, 1977

Partial purification and characterization of NADP-dependent 12α-hydroxysteroid dehydrogenase from clostridium leptum

J.N. Harris, P.B. Hylemon

Journal:

Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism

Année:

1978

Langue:

english

Fichier:

PDF, 677 KB

english, 1978

Characterization of a C21 neutral steroid hormone transforming enzyme, 21-dehydroxylase, in crude cell extracts of Eubacterium lentum

S.D. Feighner, V.D. Bokkenheuser, J. Winter, P.B. Hylemon

Journal:

Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism

Année:

1979

Langue:

english

Fichier:

PDF, 705 KB

english, 1979

Characterization of 16α-hydroxyprogesterone dehydroxylase in cell extracts of the intestinal anaerobic bacterium, Eubacterium sp. 144

Thomas L. Glass, Robin S. Lamppa, Phillip B. Hylemon

Journal:

Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism

Année:

1984

Langue:

english

Fichier:

PDF, 611 KB

english, 1984